Regulation of antibody effector functions through IgG fc N-glycosylation. IgG Fc engineering to modulate antibody effector functions. Antibody engineering for pursuing a healthier future. gene: noun a specific sequence of nucleotides in DNA or RNA that is located usually on a chromosome and that is the functional unit of inheritance controlling the transmission and expression of one or more traits by specifying the structure of a particular polypeptide and especially a protein or controlling the function of other genetic material. Read our product flyer on Clinically-relevant monoclonal antibodies.ġ. InvivoGen offers a broad range of reagents to:Īssess and compare the functions of your mAbs using our cellular assays and our extensive clinically-relevant mAb collection. The “fragment crystallizable” Fc in the constant region mediates effector functions, such as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), or complement-dependent cytotoxicity (CDC). The variable region specifically binds one antigen Monoclonal Abs display a dual activity inherent to their structure: Therefore, Ab engineering is a major translational research topic which aims at producing highly specific and effective mAbs, with optimal processing, stability, and tolerance. A challenging issue remains: the production of therapeutic mAbs and Ab-derived drugs with the highest objective response rate in patients and the lowest toxicity. Monoclonal Abs have revolutionized the fields of diagnosis and immunotherapy for the treatment of a variety of diseases, particularly in cancer therapy. Examples of antibody engineering strategiesĪntibody engineering consists of modifying monoclonal antibody (mAb) sequences and/or structures to either enhance or dampen their functions.